SMART MPOX trial:
Smallpox vaccine for Mpox post-exposure prophylaxis: a cluster randomised controlled trial
https://cepi.net/new-clinical-trial-will-assess-if-mpox-vaccination-works-after-virus-exposure
DECIPHER MPOX
The project aim is to decipher host genetics and viral determinants of Mpox pathogenesis in DRC and Uganda
https://www.nicd.ac.za/centres/centre-for-emerging-zoonotic-and-parasitic-diseases/decipher-mpox/
MPOXVAX AFRIVAC
A prospective clinical trial examining the immune response of participants receiving modified vaccinia Ankara vaccine
https://www.mpoxvaxafrivac.eu
PREGMPOX
The project aim is to investigate the impact of MPXV infection on pregnancy outcomes, immune response and placenta
https://pregmpox.org
TOKOMEZA Ebola trial
A ring vaccination trial to:
1) Evaluate the efficacy and safety of a Sudan ebolavirus vaccine and
2) Assess the lab safety and immunogenicity of a Sudan ebolavirus vaccine
https://www.gavi.org/vaccineswork/what-it-takes-launch-world-first-vaccination-trial-during-outbreak
https://www.who.int/news/item/03-02-2025-groundbreaking-ebola-vaccination-trial-launches-today-in-uganda
MOSA trial
A phase III, multi-country, randomized, placebo-controlled, double-blinded adaptive platform trial to assess the efficacy and safety of treatments for participants with M-pox virus disease
https://africacdc.org/news-item/smallpox-drug-in-clinical-trials-for-treating-mpox-in-africa/
Mpox diagnostics evaluation studies:
ICER is supporting evaluation of performance of diagnostics in the diagnosis of Mpox. These include both lateral flow devices and molecular assays.
